Understanding the Science

You may not care "how" LipoProstate Miracle™ works . . . only that it DOES work!

• If you really want to understand why LipoProstate Miracle™
  can do what no other prostate pill can . . .
• You will need to familiarize yourself with some basic life science concepts,
  which our proprietary Advanced Liposomal Delivery System™ is based on:

Bioavailability:

Bioavailability is a term used to describe how well a substance can be absorbed into our bodies.

• Some of the most important nutrients are the hardest to absorb.
• Adding insult to injury, numerous factors (including our advancing age)
  contribute to our ever decreasing ability to absorb nutrients.
• Its important to understand that absorption into the body involves two distinct phases:
• Bioaccessibility:
• absorption into the blood stream
• Bioactivity:
• absorption into the target tissues
• Water soluble nutrients are more bioaccessible than fat soluble nutrients.
• Fat soluble nutrients are much more bioactive than water soluble nutrients.

The term bioavailable is often misused, referring to just one of these 2 phases.

• To be truly bioavailable a substance must be BOTH bioaccessible AND bioactive
• There is no benefit in consuming a nutrient:
• if it can not be absorbed by the target tissue
• Nutrients can only be absorbed by the target tissue
  if they have first been absorbed into the blood stream.

Factors that Impact Bioavailability

The Bioavailability of any substance we consume is effected by:

• The physicochemical properties of the substance
• the molecular size
• the pH
• the solubility
• water soluble
• fat soluble
• The permeability of our intestines
• The cellular properties of the target cells
  • their metabolic status
  • the nature of any efflux transporters they may have
    (membrane proteins that move toxic substances out of cells)

• Each of us have unique factors that impact how well (or poorly) we absorb nutrients:
• As we age, numerous factors lead to a reduction in our bodies' ability to absorb nutrients.

Oral Delivery Systems:

A drug delivery system (DDS) is a method or route by which an active pharmaceutical (or nutraceutical) is administered to promote its desired physiological effect. The DDS can be a device or a formulation that delivers its active ingredient(s) to the target cells by controlling the rate, extent and the location of release.

Conventional Oral Delivery Systems:

Conventional drugs (defined as those developed and regulated through scientific principles) and conventional oral delivery systems such as powders, tablets, capsules, etc., have been around since the 19th century and have historically been the most widely accepted and deployed type of DDS.

Compared to other DDS's, such as intramuscular injections (IM), intravenous injections (IV) or suppositories (rectal, vaginal or urethral) . . . oral administration is greatly favored (by both patients and clinicians) due to its convenience and pain-free non-invasive nature, which results in a high degree of compliance.

Despite their popularity, oral delivery systems have a variety of drawbacks such as: potential side effects or interactions with other drugs, as well as inherent bioavailability barriers and the lack of target specificity, etc.

Over the years, there have been many technological advances in oral delivery systems. More advanced
systems are obviously still needed. However, this type of R&D faces many challenges because:

• The GI tract is not an easy path for a drug or nutrient to travel due to its wide ranging pH;
  (from the harsh acidic environment of the stomach to the alkaline environment of the colon),
  as well as its diverse make up of enzymes and microbiome.
• That alone makes designing a more advanced delivery system super challenging.
• Other variables such an individual's unique GI anatomy or bio-chemistry present additional challenges.
• And as we already discussed the unique bio-chemical properties of each active ingredient require tremendous formulation considerations.

The modern era of drug development began in the mid-20th century with breakthroughs like the discovery of penicillin in 1928 paving the way. Likewise. the modern age of drug develpment has seen numerous other breakthroughs for enhancing the bioavailability of orally-consumed nutrients:

Chelation Delivery Systems:

• Chelation is a technology that dates back to the 1930's
  and was developed to improve the bioavailability of minerals.
• Most minerals are somewhat bio-unavailable because they typically carry a charge.
  This charge (its valance) relates to the minnerals's state of free electrons in the outer
  shell of its atomic structure.
• Regardless of whether the mineral is in the form of a salt or is in an ionic state . . .
• if it has a charge . . . it will have difficulty passing through a cell membrane, due to interference from the charge of the cell membrane (just as the charge of a magnet, will either repel the same charge or attract the opposite charge). In either case, the charged minerals's ability to pass through the cell membrane will be impeded, resulting in less than optimal bioavailability.
• Chelation is an oral delivery system that improves the bioavailability of these charged minerals by wrapping an amino acid molecule around them, so that it will bind to the mineral in two spots, resulting in a neutral, stable, chelated mineral, which can then pass through the cell membrane much easier than it's unchelated ionic or salt counterpart.

Sublingual and Buccal Delivery Systems:

• Sublingual and Buccal Delivery Systems were first developed in 1950, in order
  to take advantage of the highly vascular and thin mucosa in the mouth.
• Sublingual delivery involves placing a drug under the tongue.
• Buccal delivery involves placing a drug between the gums and cheek.
• allows for rapid absorption (as in the case of sublingual nitroglycerin)
  which reaches peak plasma concentration within minutes).
• Unlike oral administration, buccal and sublingual delivery methods avoid first pass liver metabolism, resulting in faster and greater absorption into the bloodstream.

Time Released Delivery Systems:

• The first time release delivery system brought to market was in 1952
  with the advent of the Spansule® sustained-release capsule technology.
• Can deliver a drug for 12 hours after oral administration through an
  initial immediate dose followed by the remaining released gradually.

Liposomal Delivery Systems:

• Liposomes were discovered in the early 1960's
• Liposomal technology enhances bioavailability by
  outsmarting the body’s nutrient absorption barriers . . .
• first protecting a nutrient from degradation in the GI tract
• then delivering the nutrient payload(s) to the target cells
• Liposomes are able to do achieve this due to their unique structure:
  • consisting of double-layered bubbles
  • having both hydrophilic and hydrophobic properties
  • facilitates the absorption:
  • of BOTH water soluble AND fat soluble nutrients
  • into BOTH the blood system AND the target cells
• Liposomes are made of essential phospholipids.
  (the same class of lipids found in our cell membranes)

• The phosphate heads of phospholipids are hydrophilic (water-attracting):
  • Hence, they are water soluble.
• The fatty-acid tails of phospholipids are hydrophobic (water-repelling):
  • Hence, they are fat soluble.
• When phospholipids are introduced into water . . .
  • they naturally arrange themselves into double-layer structures
  • similar in appearance to an inflated tire tube, floating in a swimming pool.


• On The Inner Layer:
• The phosphate (hydrophilic) heads are oriented inward
• forming an aqueous core
• The fatty-acid (hydrophobic) tails are oriented outward
• forming the inner half of the lipid bi-layer
• On The Outer Layer:
• The fatty-acid (hydrophobic) tails are oriented inward
• facing the tails of the inner layer
• completing the lipid bi-layer
• The phosphate (hydrophilic) heads are oriented outward
• touching the water
• imparting hydrophilic properties to the entire structure

Advanced Liposomal Delivery System (ALDS)

LipoProstate Miracle™ is powerd by our proprietary Advanced Liposomal Delivery System™,
which combines time release, chealtion and liposomal technologies together in a high tech vegetable capsule

Core to ALL liposomes is a class of bio-chemicals known as phospholipids.

While developing ALDS™, we conducted feasability experiments with numerous phospholipds.
In the end, we concluded that the phospholipds best suited for ALDS™ was phosphatidycholine.
In addition to its suitability for ALDS, phosphatidycholine also has numerous health benefits .

There are a wide range of commercial food grade PC products out there - some are naturually produced,
others are synthesized. Some are less than 50% pure, while others are in the 90%+ range. As you would
expect, the more pure it is . . . the more expensive it is.

unfortunately it is also the case that the more pure it is, the more difficult it is to formulate.

We spent years (and gobs of capital) in quest of the proverbial "sweet spot" . . .
that perfect balance between purity, expense and feasability. In the end, we cracked the code . . .
achieving highly pure and stable liposomes in a cost effective delivery system.

When LipoProstate Miracle™ is swallowed (with water) . . .

• The capsule breaks down in the stomach:
• releasing phosphatidylcholine (PC) into the water
  spontaneously forming spherical (lipid bi-layer) liposomes.
• As the active ingredients are simultaneously released . . .
• Nitrogen gas accelerates their dispersion
  into the storage vesicles within the liposome,
  
• The pine sterols and vitamin D3 reside
  between the lipid biolayers
• The chelated zinc and selenium reside
  in the aqueous core.
• Once the payload is encapsulated by the liposome, it is protected
  on its journey through the harsh environment of the stomach
• After a safe exit from the stomach, the journey continues
  to the small intestine-first thru the duodenum
  and then to the jejunum, and ileum sections, where
• The liposomes can easily pass
• through the intestinal villi
• into the blood stream.
• on route to the prostate
• Upon arrival at the prostate . . .
• The liposomes merge with the prostate cells
• delivering their payload inside these target cells
  (through the process of endocytosis)

LipoProstate Miracle™ Supplement Facts